Description

(2,4-Dioxo-1,3-thiazolidin-5-yl)acetyl chloride is a versatile and highly reactive chemical building block, primarily used as a key intermediate in organic synthesis. Its core value lies in its ability to introduce the pharmacologically significant 2,4-thiazolidinedione moiety into target molecules, enabling the development of compounds with specific biological activities. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on the synthesis of novel therapeutic agents and active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of thiazolidinedione-based drugs, which are investigated for their potential in treating conditions like type 2 diabetes and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactive thiazolidinedione scaffold.
• Chemical Research & Development: Serves as a fundamental building block in medicinal chemistry for creating compound libraries and exploring new structure-activity relationships (SAR).
• Peptide Modification: Can be employed to acylate amino groups, introducing the thiazolidinedione group into peptides or other biomolecules for biochemical studies.
• Material Science: Potential use in the synthesis of specialized polymers or functional materials with unique properties derived from the heterocyclic structure.

Basic Information

Product Name	(2,4-Dioxo-1,3-thiazolidin-5-yl)acetyl Chloride
CAS No.	51226-17-6
Molecular Formula	C5H4ClNO3S
Molecular Weight	193.61 g/mol
Synonyms	5-(Chloroacetyl)-2,4-thiazolidinedione; 2,4-Thiazolidinedione, 5-(chloroacetyl)-; 5-(Chloroacetyl)thiazolidine-2,4-dione; (2,4-Dioxothiazolidin-5-yl)acetyl chloride; 5-(2-Chloro-2-oxoethyl)-1,3-thiazolidine-2,4-dione; NSC 339586
EINECS	Contact for details

Quality Control

Our (2,4-Dioxo-1,3-thiazolidin-5-yl)acetyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.