Description

N2,2'-o-Dibutyrylguanosine 3':5'-Cyclic Monophosphate Sodium Salt is a chemically modified, cell-permeable analog of cyclic guanosine monophosphate (cGMP). This compound is a critical research tool in molecular biology and pharmacology, designed to mimic the intracellular second messenger cGMP with enhanced stability and membrane permeability. It is primarily utilized by researchers in pharmaceutical R&D and academic institutions studying cellular signaling pathways, cardiovascular function, and neurological processes.

Application

• Biochemical Research: As a stable cGMP analog to study intracellular signal transduction mechanisms, particularly in the nitric oxide (NO) and protein kinase G (PKG) pathways.
• Pharmaceutical Screening: Used in high-throughput assays to identify and evaluate potential drug candidates targeting cGMP-dependent processes for cardiovascular and neurological diseases.
• Cell Physiology Studies: Investigation of smooth muscle relaxation, platelet aggregation inhibition, and neuronal plasticity in in vitro cell culture models.
• Enzyme Activation Studies: Serving as an activator for cGMP-dependent protein kinases (PKG) to elucidate their role in various physiological and pathological states.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in related pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	N2,2'-o-Dibutyrylguanosine 3':5'-Cyclic Monophosphate Sodium Salt
CAS No.	51116-00-8
Molecular Formula	C19H24N5O9PNa
Molecular Weight	528.38 g/mol
Synonyms	Dibutyryl-cGMP sodium salt; N2,2'-O-Dibutyrylguanosine 3',5'-cyclic monophosphate sodium salt; db-cGMP sodium salt; Sodium N2,2'-O-dibutyryl-3',5'-cyclic guanylate; Bt2cGMP sodium salt; Guanosine, N-[3,4-dihydro-2,5,7,8-tetrahydroxy-2-(1-oxobutoxy)methyl]-2H-1-benzopyran-2-yl]-3',5'-(hydrogen phosphate) cyclic sodium salt; 8-Bromo-cGMP analog (modified)
EINECS	Contact for details

Quality Control

Our N2,2'-o-Dibutyrylguanosine 3':5'-Cyclic Monophosphate Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Tested in cell-based assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.