Description

N2-Monobutyrylguanosine 3':5'-Cyclic Monophosphate Sodium Salt is a chemically modified derivative of cyclic guanosine monophosphate (cGMP), a crucial secondary messenger in cellular signaling pathways. This butyrylated analog is designed for enhanced membrane permeability and resistance to phosphodiesterase degradation, making it a valuable tool for probing cGMP-dependent processes. It is primarily utilized by researchers in pharmaceutical R&D, biochemistry, and molecular biology for studying signal transduction, cardiovascular function, and neurological disorders.

Application

• Biochemical Research: As a cell-permeable and hydrolysis-resistant analog of cGMP for studying intracellular signaling cascades.
• Pharmaceutical Development: Used in target validation and screening assays for drugs targeting cGMP-related pathways, such as those for hypertension and erectile dysfunction.
• Cell Biology Studies: Investigation of the role of cGMP in processes like smooth muscle relaxation, platelet aggregation, and neuronal plasticity.
• Enzyme Inhibition Studies: Serves as a stable substrate analog for research on phosphodiesterase (PDE) enzyme kinetics and inhibitor efficacy.
• Signal Transduction Probes: A key reagent for activating protein kinase G (PKG) and other cGMP-dependent effectors in experimental models.

Basic Information

Product Name	N2-Monobutyrylguanosine 3':5'-Cyclic Monophosphate Sodium Salt
CAS No.	51115-99-2
Molecular Formula	C19H23N5O8P • xNa
Molecular Weight	Contact for details
Synonyms	N2-Butyryl-cGMP sodium salt; Butyryl-cGMP; N2-Monobutyryl-guanosine-3',5'-cyclic monophosphate sodium salt; cGMP, N2-butyryl-, sodium salt; 8-Bromo-cGMP analog (butyryl); Cell-permeable cGMP analog; cGMP derivative, sodium salt
EINECS	Contact for details

Quality Control

Our N2-Monobutyrylguanosine 3':5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.