Description

2'-Azido-2'-Deoxycytidine 5'-Diphosphate is a chemically modified nucleoside diphosphate analog of critical importance in biochemical research and pharmaceutical development. This compound serves as a versatile building block and metabolic probe, enabling the study of nucleic acid synthesis and enzyme mechanisms. It is primarily utilized by research institutions, diagnostic developers, and biotechnology companies focused on antiviral drug discovery, molecular biology, and enzymology.

Application

• Biochemical Research: Acts as a substrate analog for studying DNA and RNA polymerase enzymes, including reverse transcriptase, to investigate inhibition mechanisms and nucleotide incorporation.
• Antiviral Drug Discovery: Serves as a key intermediate or probe in the development of nucleoside-based antiviral agents, particularly targeting viral polymerases.
• Enzymology Studies: Used to probe the active sites and catalytic mechanisms of kinases, phosphorylases, and other nucleotide-processing enzymes.
• Metabolic Labeling: The azido functional group allows for bioorthogonal chemistry (e.g., click chemistry) applications, enabling the tagging and tracking of nucleotide metabolism in cellular systems.
• Diagnostic Assay Development: Can be incorporated into diagnostic kits for detecting specific enzymatic activities or as a component in non-radioactive detection systems.
• Synthetic Biology: Used in the synthesis of modified oligonucleotides for exploring novel genetic codes or creating nucleic acids with enhanced properties.

Basic Information

Item	Details
Product Name	2'-Azido-2'-Deoxycytidine 5'-Diphosphate
CAS No.	51034-65-2
Molecular Formula	C9H14N6O10P2
Molecular Weight	428.19 g/mol
Synonyms	2'-Azido-2'-deoxycytidine-5'-diphosphate; 2'-N3-2'-dCDP; Azido-dCDP; 1-(2-Azido-2-deoxy-β-D-ribofuranosyl)cytosine 5'-diphosphate; 2'-Azido-2'-deoxycytidine diphosphate; 2'-Azido-dC diphosphate; 2'-N3-dCDP; Cytidine, 2'-azido-2'-deoxy-, 5'-(trihydrogen diphosphate)
EINECS	Contact for details

Quality Control

Our 2'-Azido-2'-Deoxycytidine 5'-Diphosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.