Description

3'-o-Acetylthymidine 5'-Monophosphate, Pyridinium Salt is a chemically modified nucleotide monophosphate derivative, serving as a critical building block and intermediate in advanced biochemical synthesis. Its primary value lies in enabling the controlled synthesis and study of oligonucleotides, particularly for research and development in nucleic acid chemistry. This compound is essential for pharmaceutical researchers, diagnostic developers, and academic institutions working on antiviral agents, antisense oligonucleotides, and molecular biology probes.

Application

• Oligonucleotide Synthesis: Key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands in research and therapeutic development.
• Antiviral Drug Research: Intermediate in the development of nucleoside analogue prodrugs targeting viral polymerases.
• Diagnostic Probe Development: Used to create labeled or modified probes for techniques like PCR, sequencing, and hybridization assays.
• Biochemical Tool Compound: Serves as a substrate or inhibitor in enzymatic studies of kinases, phosphatases, and polymerases.
• Prodrug Synthesis: The acetyl group provides a protective moiety that can be cleaved enzymatically in vivo, making it valuable for prodrug strategies.
• Academic & Industrial R&D: Fundamental research tool in universities and biotech companies exploring nucleic acid structure, function, and metabolism.

Basic Information

Product Name	3'-o-Acetylthymidine 5'-Monophosphate, Pyridinium Salt
CAS No.	50730-62-6
Molecular Formula	C17H22N3O9P
Molecular Weight	443.35 g/mol
Synonyms	3'-O-Acetylthymidine 5'-monophosphate pyridinium salt; Thymidine 3'-acetate 5'-(dihydrogen phosphate) pyridinium salt; 5'-TMP 3'-acetate pyridinium salt; 3'-Acetyl-5'-TMP pyridinium salt; 2'-Deoxythymidine 3'-acetate 5'-(dihydrogen phosphate) pyridinium salt; Pyridinium 3'-O-acetylthymidine 5'-monophosphate; dTMP 3'-acetate pyridinium salt
EINECS	Contact for details

Quality Control

Our production of 3'-o-Acetylthymidine 5'-Monophosphate, Pyridinium Salt adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance in GMP-related research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after opening to prevent degradation. For long-term storage, consider holding at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.