Description

O(6)-n-Butyldeoxyguanosine is a chemically modified nucleoside derivative, specifically an alkylated analog of deoxyguanosine. This compound is of significant value in biochemical research, particularly in the study of DNA damage, repair mechanisms, and mutagenesis. It serves as a critical reference standard and reagent for scientists in pharmaceutical R&D, toxicology, and academic institutions investigating the biological consequences of O6-alkylguanine lesions.

Application

• Biochemical Research Standard: Used as a high-purity reference material for calibrating analytical instruments like HPLC and LC-MS in studies of DNA adducts.
• DNA Damage & Repair Studies: Essential for investigating the mechanisms and kinetics of enzymes like O6-alkylguanine-DNA alkyltransferase (AGT) in repairing alkylated DNA.
• Mutagenesis Research: Employed to understand the mutagenic potential and replication outcomes of specific O6-alkylguanine lesions in DNA.
• Pharmaceutical Development: Acts as a key intermediate or standard in the development of chemotherapeutic agents and molecules targeting DNA repair pathways.
• Toxicology & Biomarker Analysis: Utilized in assays to quantify exposure to alkylating agents and to validate biomarkers of genotoxicity.

Basic Information

Product Name	O(6)-n-Butyldeoxyguanosine
CAS No.	50704-48-8
Molecular Formula	C14H21N5O4
Molecular Weight	323.35 g/mol
Synonyms	O6-Butyl-2'-deoxyguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(butylamino)-1H-purin-2-one; 2'-Deoxy-O6-butylguanosine; O6-n-Butyl-2'-deoxyguanosine; O6-Butyl-dG; Butyl-deoxyguanosine; O6-Butyl-deoxyguanosine
EINECS	Contact for details

Quality Control

Our O(6)-n-Butyldeoxyguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided to ensure it meets the exacting standards required for advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.