Description

7-Ethyl-2'-Deoxyguanosine is a modified nucleoside analog of deoxyguanosine, where an ethyl group is substituted at the N7 position of the guanine base. This specific structural modification makes it a valuable biochemical tool and a key intermediate in the research and development of nucleoside-based therapeutics. It is primarily utilized in advanced life science research, pharmaceutical development, and diagnostic applications. Our supply ensures high purity and batch-to-batch consistency, critical for sensitive research and manufacturing processes.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving DNA polymerases, nucleoside kinases, and other nucleic acid metabolizing enzymes.
• Antiviral & Anticancer Drug Development: Serves as a crucial building block (modified nucleoside) in the synthesis of potential prodrugs and therapeutic agents targeting viral replication or cancer cell proliferation.
• Diagnostic Probe Synthesis: Employed in the creation of labeled probes (e.g., fluorescent or radioactive) for detecting specific DNA sequences or studying nucleic acid interactions.
• Metabolic Pathway Studies: Acts as a tracer or analog to investigate the incorporation and metabolism of nucleosides within cellular systems.
• Oligonucleotide Synthesis: Incorporated into synthetic oligonucleotides to study the effects of base alkylation on DNA structure, stability, and protein binding.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, or NMR for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	7-Ethyl-2'-Deoxyguanosine
CAS No.	50704-45-5
Molecular Formula	C₁₂H₁₇N₅O₄
Molecular Weight	295.29 g/mol
Synonyms	7-Ethyl-2'-deoxyguanosine; 7-Ethyl-2'-deoxy-Guanosine; 2'-Deoxy-7-ethylguanosine; 7-Ethylguanine deoxyriboside; N⁷-Ethyl-2'-deoxyguanosine; dG⁷Et; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-ethyl-6,9-dihydro-3H-purin-6-one
EINECS	Contact for details

Quality Control

Our 7-Ethyl-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.