Description

5'-Bromoacetamido-5'-Deoxythymidine is a specialized nucleoside derivative, a key intermediate in the synthesis of modified oligonucleotides and nucleotide-based prodrugs. Its primary value lies in its reactive bromoacetamido group, which enables site-specific conjugation and labeling for advanced research and therapeutic development. This compound is essential for pharmaceutical R&D, particularly in the fields of antisense oligonucleotide synthesis, targeted drug delivery systems, and bioconjugation chemistry.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical building block for creating modified oligonucleotides with enhanced stability and targeting capabilities.
• Bioconjugation & Labeling: Used to attach reporter molecules (e.g., fluorophores, biotin) or therapeutic payloads to nucleic acids and other biomolecules.
• Prodrug Development: Serves as an intermediate in the design of nucleotide prodrugs for antiviral and anticancer therapies.
• Chemical Biology Research: A tool for studying nucleic acid-protein interactions and developing novel diagnostic probes.
• Cross-linking Agent: Utilized in the preparation of cross-linked nucleic acid structures for structural and functional studies.

Basic Information

Product Name	5'-Bromoacetamido-5'-Deoxythymidine
CAS No.	50700-63-5
Molecular Formula	C12H16BrN3O6
Molecular Weight	378.18 g/mol
Synonyms	5'-Deoxy-5'-(2-bromoacetamido)thymidine; 5'-Bromoacetamidothymidine; 5'-Bromoacetamido-5'-deoxythymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 5'-(2-bromoacetamide); 5'-(Bromoacetamido)-5'-deoxythymidine; Br-dT; Bromoacetamido-dT
EINECS	Contact for details

Quality Control

Our 5'-Bromoacetamido-5'-Deoxythymidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container in a dry, cool, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.