Description

4-Cyclooctene-1-Carbonyl Chloride (9Ci) is a highly reactive, cyclic acid chloride derivative that serves as a critical building block in advanced organic synthesis. Its strained cyclooctene ring and reactive carbonyl chloride group make it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and specialty chemical industries for applications such as peptide coupling, polymer modification, and the synthesis of novel macrocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those with macrocyclic or constrained structures.
• Peptide Chemistry: Used as a coupling agent or as a reagent to introduce the cyclooctene moiety into peptide chains for structure-activity relationship (SAR) studies.
• Polymer Science: Acts as a monomer or cross-linking agent for the production of specialty polymers with unique thermal or mechanical properties.
• Material Science: Employed in surface functionalization and the creation of advanced organic materials.
• Agrochemical Research: Serves as an intermediate in the development of new active ingredients with complex ring systems.
• Ligand Synthesis: Useful for preparing specialized ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Cyclooctene-1-Carbonyl Chloride (9Ci)
CAS No.	50653-82-2
Molecular Formula	C9H11ClO
Molecular Weight	170.64 g/mol
Synonyms	4-Cyclooctene-1-carbonyl chloride; 4-Cyclooctenecarbonyl chloride; 1-Cyclooctene-4-carbonyl chloride; Cyclooct-4-ene-1-carbonyl chloride; 4-Cyclooctenylcarbonyl chloride; 4-Cyclooctene carboxylic acid chloride; (4-Cycloocten-1-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Cyclooctene-1-Carbonyl Chloride is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our standard analytical suite includes identification by FT-IR and NMR, purity determination by GC or HPLC, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Custom purity grades and analytical specifications are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with water and alcohols; ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.