Description

2-Nitrophenyl Chloroformate is a specialized organic reagent primarily used as a versatile coupling agent and protecting group intermediate. This compound is critical for facilitating controlled chemical reactions, particularly in the synthesis of complex molecules where selective functionalization is required. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the development of active ingredients and novel polymers.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing carbamate and carbonate linkages.
• Peptide Chemistry: Used as a coupling agent in solid-phase peptide synthesis (SPPS) and for the introduction of protecting groups.
• Polymer Modification: Serves as a functional monomer or cross-linking agent in the production of specialty polymers and dendrimers.
• Agrochemical Synthesis: Intermediate in the manufacture of certain herbicides, fungicides, and plant growth regulators.
• Bioconjugation: Facilitates the labeling and modification of biomolecules (proteins, antibodies) for diagnostic and research applications.
• Chemical Research: Valuable tool in organic synthesis laboratories for method development and creating novel molecular architectures.

Basic Information

Product Name	2-Nitrophenyl Chloroformate
CAS No.	50353-00-9
Molecular Formula	C7H4ClNO4
Molecular Weight	201.56 g/mol
Synonyms	o-Nitrophenyl Chloroformate; 2-Nitrophenyl Carbonochloridate; Chloroformic Acid 2-Nitrophenyl Ester; (2-Nitrophenyl) Carbonochloridate; 2-Nitrofenylchloroformiát; NSC 404083; 2-Nitrophenyloxycarbonyl Chloride
EINECS	Contact for details

Quality Control

Our 2-Nitrophenyl Chloroformate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and identity confirmation by FT-IR and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline solid or liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.