Description

5'-Uridylic Acid, 2'-Deoxy-2'-Fluoro- is a fluorinated nucleoside monophosphate analog, a key building block in advanced oligonucleotide synthesis. This modified nucleotide is essential for creating therapeutic oligonucleotides with enhanced stability and target-binding affinity. It is primarily used by pharmaceutical R&D teams and CDMOs developing next-generation antisense oligonucleotides, siRNA, and mRNA-based therapeutics.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical raw material for constructing oligonucleotides designed to modulate gene expression for therapeutic applications.
• Small Interfering RNA (siRNA) Production: Used to incorporate fluorine modifications into the siRNA backbone, improving nuclease resistance and pharmacokinetic properties.
• Research & Diagnostic Probe Development: Employed in the synthesis of labeled probes and primers for molecular biology research and diagnostic assays requiring high specificity.
• mRNA Vaccine & Therapeutic Platform: Serves as a modified nucleotide for potential use in mRNA constructs to reduce immunogenicity and enhance translational efficiency.
• Medicinal Chemistry & Drug Discovery: A valuable intermediate for medicinal chemists exploring novel nucleoside-based antiviral and anticancer agents.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs as a high-purity GMP-grade starting material for cGMP-compliant oligonucleotide manufacturing.

Basic Information

Product Name	5'-Uridylic Acid, 2'-Deoxy-2'-Fluoro-
CAS No.	50270-97-8
Molecular Formula	C9H12FN2O8P
Molecular Weight	326.17 g/mol
Synonyms	2'-Deoxy-2'-fluorouridine 5'-monophosphate; 2'-F-dUMP; 2'-Fluoro-2'-deoxyuridine 5'-monophosphate; 5'-UMP-2'-F; 2'-Fluoro-2'-deoxyuridylic acid; FdUMP; 2'-F-2'-dUMP; 2'-Fluorodeoxyuridine monophosphate
EINECS	Contact for details

Quality Control

Our 5'-Uridylic Acid, 2'-Deoxy-2'-Fluoro- is manufactured under strict quality systems. We offer material suitable for research through to cGMP-grade for therapeutic applications, with comprehensive testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each batch, detailing specifications such as assay (HPLC), chiral purity, and impurity profiles. We support compliance with ICH Q7 guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥95.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.