Description

Lonidamine CAS NO 50264-69-2 is a synthetic indazole carboxylic acid derivative with significant research and pharmaceutical interest. This compound matters as a targeted metabolic inhibitor, primarily studied for its ability to interfere with energy production in specific cell types. It is needed by pharmaceutical R&D teams, academic research institutions, and fine chemical suppliers focused on developing and producing novel therapeutic agents for oncology and other metabolic disorders.

Application

• Pharmaceutical Research & Development: As a key intermediate or active pharmaceutical ingredient (API) in preclinical and clinical studies for novel cancer therapeutics.
• Oncology Mechanism Studies: Used in biochemical research to study the inhibition of mitochondrial hexokinase and energy metabolism in tumor cells.
• Fine Chemical Synthesis: Serves as a crucial building block for the synthesis of more complex molecules and analogs in medicinal chemistry.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation in pharmaceutical manufacturing.
• Biochemical Reagent: Employed in vitro to investigate sperm cell metabolism and its potential applications in male fertility research.
• Academic Research: A tool compound for studying cell bioenergetics, apoptosis induction, and the sensitization of cells to other treatment modalities.

Basic Information

Product Name	Lonidamine
CAS No.	50264-69-2
Molecular Formula	C15H10Cl2N2O2
Molecular Weight	321.16 g/mol
Synonyms	1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid; AF 1890; DICA; LND; Doridamina; Lonidamin; Lonicid; Lonicidamin; NSC-290205; Tereblin
EINECS	256-464-8

Quality Control

Our Lonidamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure compliance with high-purity standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.