Description

14-Hydroxyestrone is a significant hydroxylated metabolite of the primary female sex hormone, estrone. This compound is of high interest in biochemical research and pharmaceutical development due to its role in estrogen metabolism and potential biological activity. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector. Key industries requiring this compound include pharmaceutical R&D, academic research institutions, and diagnostic kit development.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of estrogen metabolites in drug development and quality control laboratories.
• Biochemical Research: Employed in studies investigating estrogen metabolism pathways, enzyme kinetics, and hormonal regulation mechanisms.
• Diagnostic Reagent Intermediate: Serves as a key starting material or calibrant in the production of immunoassays and diagnostic tests for hormonal status.
• Metabolite Profiling: Essential for creating metabolite panels in clinical and preclinical studies to understand drug interactions and endocrine effects.
• Academic & Institutional Research: A vital tool for universities and research institutes conducting fundamental endocrinology and cancer research.

Basic Information

Product Name	14-Hydroxyestrone
CAS No.	5949-46-2
Molecular Formula	C18H22O3
Molecular Weight	286.36 g/mol
Synonyms	14-Hydroxyestrone; 14-Hydroxyoestrone; Estrone, 14-hydroxy-; 3-Hydroxyestra-1,3,5(10)-trien-14-one; 14-OH-Estrone; 14-OHE1; Estra-1,3,5(10)-trien-14-one, 3-hydroxy-
EINECS	Contact for details

Quality Control

Our 14-Hydroxyestrone is produced under a rigorous quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can support development projects requiring compliance with various pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.