Description

Trimethyl Phosphonoacetate is a versatile organophosphorus compound that serves as a key building block in organic synthesis. Its primary value lies in its role as a reagent for the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient production of α,β-unsaturated esters and other valuable intermediates. This chemical is essential for research and development laboratories and industrial-scale manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors.

Application

• Key reagent in the Horner-Wadsworth-Emmons (HWE) olefination for synthesizing alkenes.
• Building block for the synthesis of phosphonate analogs of biologically active molecules.
• Intermediate in the production of pharmaceutical actives, including potential antiviral and enzyme inhibitor compounds.
• Precursor for agrochemicals such as herbicides and plant growth regulators.
• Used in material science for creating functionalized polymers and ligands for catalysis.
• Starting material for fine chemicals and flavor & fragrance ingredients.

Basic Information

Product Name	Trimethyl Phosphonoacetate
CAS No.	5927-18-4
Molecular Formula	C5H11O5P
Molecular Weight	182.11 g/mol
Synonyms	Trimethyl (Acetoxyphosphinyl)acetate; (Acetoxyphosphinyl)acetic Acid Trimethyl Ester; Acetic Acid, (Acetoxyphosphinyl)-, Trimethyl Ester; Phosphonoacetic Acid Trimethyl Ester; Dimethyl (Methoxycarbonylmethyl) Phosphonate; (Methoxycarbonylmethyl)phosphonic Acid Dimethyl Ester; Trimethyl Acetoxyphosphinylacetate; HWE Reagent Precursor
EINECS	227-667-6

Quality Control

Our Trimethyl Phosphonoacetate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, keep the container tightly sealed when not in use to prevent moisture absorption, which may affect product quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.