Description

2,2-Dimethylbutyryl Chloride is a versatile acid chloride derivative of 2,2-dimethylbutyric acid, serving as a critical acylating and building block agent in advanced organic synthesis. Its value lies in introducing the sterically hindered 2,2-dimethylbutyryl moiety, which is instrumental in modifying the physical and biological properties of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating prodrugs or modifying drug molecules to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where the bulky dimethylbutyryl group can improve efficacy and environmental profile.
• Polymer Chemistry: Acts as a modifying agent or chain terminator in the synthesis of specialty polymers, including polyamides and polyesters, to alter thermal and mechanical properties.
• Peptide & Protein Modification: Employed as an acylating reagent for modifying amino groups on peptides or proteins, useful in biochemical research and bioconjugation.
• Dye and Pigment Manufacturing: Serves as an intermediate in the synthesis of specialized dyes and organic pigments, contributing to color fastness and solubility characteristics.
• Flavor and Fragrance Industry: Utilized in the controlled synthesis of esters and other compounds that contribute to complex flavor and fragrance profiles.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation and other reactions to introduce the tertiary acid chloride functionality into aromatic and aliphatic systems.
• Material Science Research: Used in surface modification and the creation of novel organic-inorganic hybrid materials with tailored surface properties.

Basic Information

Product Name	2,2-Dimethylbutyryl Chloride
CAS No.	5856-77-9
Molecular Formula	C6H11ClO
Molecular Weight	134.60 g/mol
Synonyms	Pivaloyl Chloride, 2,2-Dimethylpropionyl Chloride; Trimethylacetyl Chloride; 2,2-Dimethylpropanoic Acid Chloride; Pivalic Acid Chloride; 2,2-Dimethylbutanoyl Chloride; Butanoyl chloride, 2,2-dimethyl-; NSC 9375
EINECS	227-476-2

Quality Control

Our 2,2-Dimethylbutyryl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified for specific grades. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 1.0% (as HCl)
Density at 20°C	0.98 - 1.02 g/mL
Refractive Index (n20/D)	1.410 - 1.430

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.