Description

2',3'-o-Isopropylidene-6-Thioinosine is a chemically modified nucleoside derivative, serving as a crucial synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its role as a protected precursor for the synthesis of novel thiopurine analogs and modified nucleotides, enabling the exploration of new therapeutic agents. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on antiviral, anticancer, and other nucleoside-based drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel thiopurine nucleoside analogs with potential therapeutic activity.
• Antiviral Drug Research: Used in the development and study of modified nucleosides targeting viral replication mechanisms.
• Anticancer Agent Development: Serves as a precursor in creating purine analogs that may interfere with cancer cell proliferation.
• Biochemical Research: Employed in studies of enzyme inhibition, nucleotide metabolism, and structure-activity relationships (SAR).
• Prodrug Synthesis: Utilized in designing prodrugs to improve the bioavailability and targeting of active nucleoside drugs.
• Life Science Reagents: Acts as a specialized reagent for labeling, probing, or modifying nucleic acid structures in research settings.

Basic Information

Item	Details
Product Name	2',3'-o-Isopropylidene-6-Thioinosine
CAS No.	5856-48-4
Molecular Formula	C₁₃H₁₆N₄O₄S
Molecular Weight	324.36 g/mol
Synonyms	6-Thioinosine, 2',3'-O-Isopropylidene-; 6-Mercaptopurine riboside, 2',3'-O-Isopropylidene-; 2',3'-O-Isopropylidene-6-mercaptopurine riboside; 6-Thio-2',3'-O-isopropylideneinosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-6-sulfanylpurine (protected form); 6-MP riboside acetonide; 6-Thioinosine acetonide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2',3'-o-Isopropylidene-6-Thioinosine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization and purity verification. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.