Description

8-Hydroxyguanine is a significant oxidized derivative of guanine, a key nucleobase in DNA and RNA. This compound matters as a critical biomarker for oxidative stress and DNA damage, playing a pivotal role in understanding cellular aging, mutagenesis, and various disease pathologies. It is primarily needed by researchers and manufacturers in the fields of pharmaceutical development, life science research, diagnostic reagent production, and biochemical studies.

Application

• Biomarker Research: Used as a standard and probe in studies of oxidative DNA/RNA damage, aging, and cancer mechanisms.
• Pharmaceutical Development: Serves as a reference compound in the research and development of drugs targeting oxidative stress-related diseases, such as neurodegenerative disorders.
• Diagnostic Reagents: Employed in the formulation of kits and assays for the detection and quantification of oxidative damage in clinical and research settings.
• Biochemical Studies: Utilized in enzymatic studies, particularly those involving DNA repair enzymes like 8-oxoguanine DNA glycosylase (OGG1).
• Toxicology & Safety Assessment: Acts as a critical parameter in evaluating the genotoxic effects of chemicals, environmental pollutants, and radiation.
• Academic Research: Fundamental tool in university and institutional labs for molecular biology, genetics, and free radical chemistry projects.

Basic Information

Product Name	8-Hydroxyguanine
CAS No.	5814-64-2
Molecular Formula	C5H5N5O2
Molecular Weight	167.13 g/mol
Synonyms	8-Oxoguanine; 8-Oxo-7,8-dihydroguanine; 7,8-Dihydro-8-oxoguanine; 8-OH-Gua; 8-Hydroxy-2'-deoxyguanosine precursor; OxoG; 8-Oxo-G; Guanine, 8-hydroxy-
EINECS	Contact for details

Quality Control

Our 8-Hydroxyguanine is produced under stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere for long-term preservation and to minimize exposure to air after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.