Description

(22R)-5,6β-Epoxy-22,27-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid δ-Lactone is a high-purity steroidal lactone compound of significant interest in advanced organic synthesis and pharmaceutical research. This specialized ergostane derivative serves as a critical synthetic intermediate and reference standard for developing novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of steroid-based therapeutics and the study of complex natural product biosynthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroid-based drugs and active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in academic and industrial research to study enzyme interactions, metabolic pathways, and the structure-activity relationships of steroidal compounds.
• Natural Product Synthesis: Serves as a sophisticated starting material or intermediate for the total or semi-synthesis of complex natural products derived from ergostane.
• Process Chemistry: Utilized in scaling up synthetic routes for the production of high-value specialty chemicals in a GMP or non-GMP environment.

Basic Information

Product Name	(22R)-5,6β-Epoxy-22,27-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid δ-Lactone
CAS No.	5788-94-3
Molecular Formula	C28H36O6
Molecular Weight	468.59 g/mol
Synonyms	5,6α-Epoxy-22,27-dihydroxy-1-oxo-5α-ergosta-2,24-dien-26-oic acid δ-lactone; 22R-Hydroxywithanolide E; (22R)-27-Hydroxywithanolide E; Withanolide E 22R-epimer; 5,6β-Epoxy-22,27-dihydroxy-1-oxo-5β-ergosta-2,24-dien-26-oic acid δ-lactone; Jaborosalactone 39; A compound of the Withanolide class.
EINECS	Contact for details

Quality Control

Our (22R)-5,6β-Epoxy-22,27-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid δ-Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.