Description

Levopropoxyphene Napsilate is a synthetic pharmaceutical compound primarily used as an antitussive agent. Its value lies in its specific action on the cough reflex, offering a targeted therapeutic effect for the development of cough suppressant formulations. This product is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of respiratory medications, including prescription and over-the-counter cough syrups and lozenges.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in antitussive (cough suppressant) medications.
• Prescription Cough Syrups: Formulation into liquid dosage forms for controlled, prescription-based cough management.
• Over-the-Counter (OTC) Remedies: Incorporation into non-prescription cough drops, syrups, and lozenges.
• Respiratory Research: Serving as a reference standard or investigational compound in pharmacological studies related to cough mechanisms.
• Drug Development: Used in the R&D phase for creating new or improved cough relief formulations with optimized efficacy and safety profiles.
• Generic Drug Manufacturing: Key ingredient for producing generic versions of established antitussive medications containing levopropoxyphene napsilate.

Basic Information

Product Name	Levopropoxyphene Napsilate
CAS No.	5714-90-9
Molecular Formula	C22H29NO2 • C10H8O3S
Molecular Weight	565.73 g/mol
Synonyms	Levopropoxyphene Napsylate; (-)-α-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol Propionate Ester 2-Naphthalenesulfonate; Novrad (as napsylate salt); S-(-)-Propoxyphene Napsylate; Levopropoxyphene 2-Naphthalenesulfonate; (2S,3R)-4-(Dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propionate 2-naphthalenesulfonate; α-d-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate 2-naphthalenesulfonate
EINECS	227-173-9

Quality Control

Our Levopropoxyphene Napsilate is manufactured and tested under strict quality management systems. We ensure compliance with relevant pharmaceutical standards, and the product is suitable for use in GMP (Good Manufacturing Practice) environments. Comprehensive testing is performed to verify identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Rotation	-57° to -62° (c = 1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.