Description

3,3',5'-Triiodo-D-Thyronine is a stereoisomer of the endogenous thyroid hormone triiodothyronine (T3). This compound matters as a critical biochemical tool and reference standard for research into thyroid hormone action, metabolism, and receptor binding studies. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic kits for use in metabolic studies, endocrine research, and as a high-purity analytical standard.

Application

• Biochemical Research: Used as a reference compound in studies of thyroid hormone receptors (TRα and TRβ), gene expression, and metabolic pathways.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development and quality control of thyroid hormone analogs and related therapeutics.
• Diagnostic Manufacturing: Employed in the production and calibration of immunoassay kits (e.g., ELISA, RIA) for the quantitative measurement of thyroid hormones.
• Metabolic Studies: Utilized in in vitro and in vivo research to investigate the effects of thyroid hormones on metabolism, thermogenesis, and cardiac function.
• Analytical Standard: Acts as a high-purity certified reference material (CRM) for HPLC, LC-MS, and other analytical methods to ensure accuracy in quantification.

Basic Information

Product Name	3,3',5'-Triiodo-D-Thyronine
CAS No.	5714-08-9
Molecular Formula	C15H11I3NO4
Molecular Weight	650.96 g/mol
Synonyms	D-Triiodothyronine; D-T3; D-3,3',5-Triiodothyronine; (R)-3,3',5-Triiodothyronine; (R)-T3; D-Thyronine, 3,3',5-triiodo-; Reverse T3 isomer; 3,3',5-Triiodo-D-thyronine; D-3,3',5-Triiodo-L-thyronine (archaic)
EINECS	227-193-6

Quality Control

Our 3,3',5'-Triiodo-D-Thyronine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets high-purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.