Description

2-Phenylcyclopropanecarbonyl Chloride is a specialized organic building block characterized by its reactive acid chloride functional group attached to a phenyl-substituted cyclopropane ring. This compound matters as a key intermediate for introducing the constrained, three-membered cyclopropane ring into target molecules, a structural motif valued in medicinal chemistry for its ability to modulate conformation and metabolic stability. Pharmaceutical researchers and fine chemical manufacturers need it for the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, where the cyclopropane moiety can enhance blood-brain barrier penetration.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging its unique structure to create compounds with specific biological activity.
• Peptide Mimetics & Bioisosteres: Employed to construct cyclopropane-containing amino acid analogs, which are valuable tools in peptide research for improving stability and potency.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored thermal or mechanical properties.
• Chemical Biology Probes: Utilized to create activity-based probes or affinity labels for studying enzyme function and protein interactions.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing chiral ligands or organocatalysts containing the cyclopropane scaffold.

Basic Information

Product Name	2-Phenylcyclopropanecarbonyl Chloride
CAS No.	5685-36-9
Molecular Formula	C10H9ClO
Molecular Weight	180.63 g/mol
Synonyms	2-Phenylcyclopropanecarboxylic Acid Chloride; 2-Phenylcyclopropanecarboxyl Chloride; Cyclopropanecarbonyl Chloride, 2-Phenyl-; (2-Phenylcyclopropyl)carbonyl Chloride; α-Phenylcyclopropanecarbonyl Chloride; 1-Cyclopropyl-1-phenylmethanoyl Chloride; 5685-36-9
EINECS	Contact for details

Quality Control

Our 2-Phenylcyclopropanecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.