Description

5,6-Dihydrodeoxyuridine is a modified nucleoside derivative of deoxyuridine, characterized by the saturation of the 5,6-double bond in the pyrimidine ring. This structural modification makes it a valuable intermediate and reference standard in pharmaceutical research and development, particularly in the study of nucleoside metabolism and antiviral/anticancer drug mechanisms. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents and biochemical studies. The compound is supplied with a focus on high purity and batch-to-batch consistency to meet stringent research and production requirements.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies related to thymidylate synthase and other nucleotide metabolic pathways.
• Metabolite Analysis: Serves as a standard for the identification and quantification of dihydropyrimidine derivatives in metabolic profiling.
• Medicinal Chemistry: A crucial precursor for structure-activity relationship (SAR) studies to develop new therapeutic agents targeting DNA synthesis.
• Academic Research: Employed in university and institutional labs for fundamental studies in nucleic acid chemistry and enzymology.
• Process Development: Used in scaling up and optimizing synthetic routes for complex nucleoside analogs in pilot and commercial manufacturing.

Basic Information

Product Name	5,6-Dihydrodeoxyuridine
CAS No.	5626-99-3
Molecular Formula	C9H14N2O5
Molecular Weight	230.22 g/mol
Synonyms	5,6-Dihydro-2'-deoxyuridine; 5,6-Dihydrothymidine (common misnomer); Dihydrodeoxyuridine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5,6-dihydropyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-5,6-dihydrouridine; 5,6-DHUrd; DHdU
EINECS	Contact for details

Quality Control

Our 5,6-Dihydrodeoxyuridine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.