Description

4-Thio-2'-Deoxyuridine is a chemically modified nucleoside analog where the oxygen atom at the 4-position of the pyrimidine ring is replaced by sulfur. This structural modification is critical for its role as a key intermediate and building block in the synthesis of novel oligonucleotides and therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, diagnostic probes, and advanced nucleic acid research.

Application

• Antiviral Drug Development: Serves as a crucial precursor in the synthesis of nucleoside analogs targeting viral polymerases.
• Oligonucleotide Synthesis: Used as a modified building block to introduce specific functionalities into DNA/RNA sequences for research and therapeutic applications.
• Biochemical Research: Acts as a tool compound for studying enzyme mechanisms, particularly those involving thymidine phosphorylase and other nucleoside-metabolizing enzymes.
• Diagnostic Probe Design: Incorporated into nucleic acid probes to enhance stability or alter hybridization properties for diagnostic assays.
• Radiopharmaceuticals: Potential intermediate for the synthesis of radiolabeled compounds used in medical imaging.
• Academic & Industrial R&D: Fundamental material for exploring new chemical entities in medicinal chemistry and molecular biology.

Basic Information

Product Name	4-Thio-2'-Deoxyuridine
CAS No.	5580-20-1
Molecular Formula	C9H12N2O4S
Molecular Weight	244.27 g/mol
Synonyms	4-Thio-2'-deoxyuridine; 2'-Deoxy-4-thiouridine; 4-Thiouridine deoxyriboside; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-sulfanylpyrimidin-2(1H)-one; 4-Sulfanyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; d4SU; 4-Thio-dUrd
EINECS	Contact for details

Quality Control

Our 4-Thio-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.