Description

n-[4-(2-Bromoacetyl)Phenyl]Methanesulfonamide CAS NO 5577-42-4 is a specialized bromoacetyl derivative and methanesulfonamide compound that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both an electrophilic bromoacetyl group and a sulfonamide moiety, makes it a versatile intermediate for constructing complex pharmacophores and functional materials. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality building blocks for drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small molecule drugs, particularly those targeting enzyme inhibition via sulfonamide and ketone functionalities.
• Agrochemical Synthesis: Used in the research and development of new herbicides and pesticides, where the bromoacetyl group enables further derivatization.
• Chemical Biology & Proteomics: Serves as an active-site directed labeling agent or a building block for activity-based probes (ABPs) due to its reactive α-haloketone group.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials requiring specific sulfonamide linkages.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for creating compound libraries for high-throughput screening.

Basic Information

Product Name	n-[4-(2-Bromoacetyl)Phenyl]Methanesulfonamide
CAS No.	5577-42-4
Molecular Formula	C9H10BrNO3S
Molecular Weight	292.15 g/mol
Synonyms	4'-(Bromoacetyl)methanesulfonanilide; N-[4-(2-Bromoacetyl)phenyl]methanesulfonamide; 1-(4-(Methylsulfonamido)phenyl)-2-bromoethan-1-one; Methanesulfonamide, N-[4-(2-bromoacetyl)phenyl]-; p-(Bromoacetyl)phenyl methanesulfonamide; Bromoacetyl Methanesulfonanilide; 5577-42-4; BAPMSA
EINECS	Contact for details

Quality Control

Our n-[4-(2-Bromoacetyl)Phenyl]Methanesulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture uptake. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.