Description

Guanosine 5'-Monophosphate Disodium Salt is a high-purity nucleotide salt essential for biochemical and pharmaceutical research and manufacturing. This compound serves as a critical building block and precursor in the synthesis of nucleic acids, oligonucleotides, and various bioactive molecules. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies developing therapeutics, vaccines, and molecular biology reagents.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of antiviral drugs (e.g., nucleoside analogs) and mRNA vaccine components.
• Biochemical Research: Essential substrate for enzymatic studies, polymerase chain reaction (PCR), and in vitro transcription systems.
• Diagnostic Reagent Manufacturing: Used in the production of probes, primers, and kits for genetic testing and molecular diagnostics.
• Cell Culture & Media Supplement: Acts as a nucleotide source in specialized cell culture media for biotechnology applications.
• Food Flavor Enhancer (Disodium 5'-Guanylate, GMP): When meeting food-grade specifications (FCC), it is used as a flavor enhancer, often in synergy with monosodium glutamate (MSG).
• Reference Standard: Serves as an analytical standard in quality control laboratories for HPLC, LC-MS, and other chromatographic methods.

Basic Information

Product Name	Guanosine 5'-Monophosphate Disodium Salt
CAS No.	5550-12-9
Molecular Formula	C10H12N5Na2O8P
Molecular Weight	407.17 g/mol
Synonyms	5'-GMP Disodium Salt; Disodium Guanosine 5'-Monophosphate; Disodium 5'-Guanylate; GMP Disodium Salt; Sodium Guanosine 5'-Monophosphate; Guanosine 5'-(Disodium Phosphate); Disodium Guanosine 5'-Phosphate; E626
EINECS	226-914-1

Quality Control

Our Guanosine 5'-Monophosphate Disodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and heavy metals. We provide material suitable for research, pharmaceutical, and food-grade applications, with compliance to relevant sections of USP, EP, and FCC monographs where applicable. A detailed Certificate of Analysis (COA) is available for every lot to ensure traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤8.0%
pH (5% Solution)	7.0 - 9.0
Heavy Metals (as Pb)	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	<1.0 EU/mg (if applicable)
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13 (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.