Description

o-Acetylsalicyloyl Chloride is a key acyl chloride intermediate derived from salicylic acid, prized for its high reactivity in introducing the acetylsalicyloyl moiety. This compound matters for its critical role in the efficient synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for producing active pharmaceutical ingredients (APIs), prodrugs, and specialized organic compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of salicylate-based drugs and prodrugs.
• API Synthesis: Used in the manufacturing of active pharmaceutical ingredients (APIs) requiring the acetylsalicyloyl functional group.
• Prodrug Development: Employed in research and production of prodrugs to enhance drug delivery and bioavailability.
• Fine Chemical Production: Serves as a versatile reagent for acylations and esterifications in custom synthesis.
• Agrochemical Synthesis: Used in the creation of specialized herbicides and plant protection agents.
• Bioconjugation & Labeling: Applicable in biochemical research for modifying proteins or other biomolecules.
• Polymer Chemistry: Can act as a monomer or modifying agent for specialty polymers.
• Academic & Industrial R&D: A valuable reagent for exploratory organic synthesis and process development.

Basic Information

Item	Details
Product Name	o-Acetylsalicyloyl Chloride
CAS No.	5538-51-2
Molecular Formula	C9H7ClO3
Molecular Weight	198.60 g/mol
Synonyms	2-(Acetyloxy)benzoyl chloride; Acetylsalicyloyl chloride; Aspirinoyl chloride; o-Acetoxybenzoyl chloride; 2-Acetoxybenzoyl chloride; Acetylsalicylyl chloride; Acetylsalicyl chloride; Salicylic acid acetate chloride
EINECS	226-882-6

Quality Control

Our o-Acetylsalicyloyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay and impurity profiling by HPLC, to ensure it meets high-purity standards suitable for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water and strong bases; ensure containers are kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, open flames, and incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.