Description

5-Amino-2'-Deoxyuridine Free Base is a modified nucleoside analog of deoxyuridine, featuring an amino group substitution at the 5-position of the uracil ring. This structural modification makes it a valuable biochemical tool and a key intermediate in the research and development of antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in nucleoside chemistry and molecular biology. The compound's unique structure allows for the study of DNA synthesis inhibition and the development of novel therapeutic compounds.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to thymidylate synthase and DNA polymerases.
• Molecular Biology Probe: Serves as a tool for studying DNA replication, repair mechanisms, and cell cycle progression.
• Antiviral Agent Development: A precursor in the research of compounds targeting viral DNA synthesis, such as herpesviruses.
• Labeled Compound Synthesis: Used to prepare radiolabeled or fluorescently tagged derivatives for tracer studies and diagnostic applications.
• Academic & Industrial R&D: Fundamental research material in universities and corporate labs focusing on medicinal chemistry and drug discovery.

Basic Information

Product Name	5-Amino-2'-Deoxyuridine Free Base
CAS No.	5536-30-1
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	5-Amino-2'-deoxyuridine; 5-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 5-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil; 5-Amino-dU; 5-NH2-dU; AdUrd; 5-Amino-deoxyuridine
EINECS	226-886-7

Quality Control

Our 5-Amino-2'-Deoxyuridine Free Base is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades, including research and pharmaceutical intermediate standards, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.