Description

2H-Isoindole-2-Carbonyl Chloride, 1,3-Dihydro-1,3-Dioxo- (9Ci) is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its value lies in its role as a versatile acylating and coupling agent, enabling the efficient construction of complex heterocyclic and pharmaceutical scaffolds. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of isoindole-based drug candidates, including kinase inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific heterocyclic frameworks.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers with unique thermal or mechanical properties.
• Material Science Research: Employed in the development of organic semiconductors, dyes, and photoactive materials.
• Peptide Mimetics & Conjugation: Facilitates the introduction of the isoindole-1,3-dione (phthalimide) moiety into peptides and proteins for bioconjugation and prodrug strategies.
• Chemical Research & Development: A critical reagent for method development and exploring new reaction pathways in academic and industrial R&D laboratories.

Basic Information

Product Name	2H-Isoindole-2-Carbonyl Chloride, 1,3-Dihydro-1,3-Dioxo- (9Ci)
CAS No.	5511-75-1
Molecular Formula	C9H4ClNO3
Molecular Weight	209.59 g/mol
Synonyms	1,3-Dioxoisoindole-2-carbonyl chloride; Phthalimido carbonyl chloride; N-Phthaloylglycine acid chloride; 2-Phthalimidoacetyl chloride; Isoindole-1,3(2H)-dione, 2-(chlorocarbonyl)-; 2-Carboxyphthalimide chloride; Phthalimide-N-acetic acid chloride; N-(Chloroformyl)phthalimide
EINECS	226-852-5

Quality Control

Our 2H-Isoindole-2-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.