Description

3-Trimethylsilyl-2-Propyn-1-Ol CAS NO 5272-36-6 is a versatile organosilicon building block featuring both a silyl-protected alkyne and a hydroxyl functional group. This bifunctional nature makes it a critical intermediate for constructing complex molecular architectures in advanced organic synthesis. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions, click chemistry, and polymer modification.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing alkyne handles for bioconjugation via click chemistry (e.g., CuAAC).
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where its functional groups allow for the creation of compounds with specific biological activity.
• Material Science & Polymer Chemistry: Acts as a monomer or cross-linking agent for synthesizing specialty silicones, silicon-containing polymers, and advanced hybrid organic-inorganic materials.
• Ligand & Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysis, enhancing reaction selectivity and efficiency.
• Protecting Group Strategy: The trimethylsilyl (TMS) group protects the terminal alkyne during multi-step syntheses, which can be selectively deprotected under mild conditions.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular libraries for screening.

Basic Information

Product Name	3-Trimethylsilyl-2-Propyn-1-Ol
CAS No.	5272-36-6
Molecular Formula	C6H12OSi
Molecular Weight	128.25 g/mol
Synonyms	3-(Trimethylsilyl)-2-propyn-1-ol; 3-(Trimethylsilyl)prop-2-yn-1-ol; 2-Propyn-1-ol, 3-(trimethylsilyl)-; TMS-Propargyl Alcohol; Trimethylsilylpropargyl Alcohol; (Trimethylsilyl)propargyl Alcohol; 3-Trimethylsilylpropagyl Alcohol; Propargyl Alcohol, 3-Trimethylsilyl-
EINECS	226-092-4

Quality Control

Our production of 3-Trimethylsilyl-2-Propyn-1-Ol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.