Description

2-Methyl-4-Trimethylsilyl-3-Butyn-2-Ol is a versatile organosilicon building block featuring both a silyl-protected alkyne and a tertiary alcohol functional group. This unique bifunctional structure makes it a valuable intermediate for the controlled synthesis of complex molecules in advanced research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing acetylene units in a protected form.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the silyl-protected alkyne moiety is crucial for bioactivity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and silicon-containing advanced materials.
• Organic Synthesis Building Block: Employed in Sonogashira coupling and other metal-catalyzed reactions to create complex alkynes and conjugated systems.
• Ligand and Catalyst Development: Utilized for constructing sophisticated ligand frameworks in homogeneous catalysis.
• Academic and Industrial R&D: A critical reagent for methodological development and exploring new synthetic pathways in chemistry research.

Basic Information

Product Name	2-Methyl-4-Trimethylsilyl-3-Butyn-2-Ol
CAS No.	5272-33-3
Molecular Formula	C8H16OSi
Molecular Weight	156.30 g/mol
Synonyms	3-Butyn-2-ol, 2-methyl-4-(trimethylsilyl)-; 2-Methyl-4-(trimethylsilyl)-3-butyn-2-ol; 4-(Trimethylsilyl)-2-methyl-3-butyn-2-ol; TMS-Protected Propargylic Alcohol; Trimethyl(3-hydroxy-3-methyl-1-butyn-1-yl)silane; 3-Hydroxy-3-methyl-1-(trimethylsilyl)-1-butyne
EINECS	226-085-3

Quality Control

Our 2-Methyl-4-Trimethylsilyl-3-Butyn-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.