Description

Tipepidine is a synthetic, non-narcotic antitussive agent known for its central action in suppressing cough reflexes. This compound is valued for its specific pharmacological activity and is a key intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of cough suppressants and related therapeutic formulations. Tipepidine CAS NO 5169-78-8 is supplied under stringent quality control to ensure batch-to-batch consistency for critical applications.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of finished antitussive (cough suppressant) drugs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as the core active component in formulated cough syrup and tablet production.
• Pharmacological Research: Used in preclinical and clinical studies to investigate mechanisms of cough suppression and central nervous system effects.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Veterinary Pharmaceuticals: Potential application in the development of cough medications for animal health.

Basic Information

Product Name	Tipepidine
CAS No.	5169-78-8
Molecular Formula	C14H19NS
Molecular Weight	233.37 g/mol
Synonyms	1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carbothioamide; Tipepidine Hibenzate (salt form); Antitux; Tipepidine Citrate; Asverin (brand name); TPD; 3-Thiocarbamoyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole
EINECS	Contact for details

Quality Control

Our Tipepidine is manufactured and tested under a quality management system to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via techniques such as HPLC and NMR. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can support compliance with cGMP, ICH Q7, and other relevant pharmacopeial guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.