Description

5-Hydroxy-2'-Deoxyuridine is a modified nucleoside analog of deoxyuridine, featuring a hydroxyl group at the 5-position of the uracil base. This structural modification makes it a valuable biochemical tool and a key intermediate in the research and synthesis of nucleoside-based pharmaceuticals. It is primarily sought after by research institutions and pharmaceutical developers working in the fields of oncology, virology, and molecular biology. The compound's role in studying DNA metabolism and as a precursor for novel therapeutic agents underscores its importance in advanced life science applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to thymidylate synthase and other nucleotide-metabolizing enzymes.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthetic pathways for novel anticancer and antiviral prodrugs.
• Metabolic Pathway Analysis: Employed as a tracer or analog to investigate DNA synthesis, repair mechanisms, and cell proliferation studies.
• Reference Standard: Utilized as a high-purity analytical standard in HPLC, LC-MS, or NMR for quality control and method development in pharmaceutical analysis.
• Antiviral Agent Development: Investigated for its potential incorporation into oligonucleotides targeting viral replication.
• Radioprotector & Chemosensitizer Research: Studied for its modulatory effects on cellular response to radiation and chemotherapy.

Basic Information

Item	Detail
Product Name	5-Hydroxy-2'-Deoxyuridine
CAS No.	5168-36-5
Molecular Formula	C9H12N2O6
Molecular Weight	244.20 g/mol
Synonyms	5-OH-dU; 5-HydroxydUrd; 5-Hydroxy-2'-deoxyuridine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxypyrimidine-2,4(1H,3H)-dione; 5-Hydroxy-1-((2-deoxy-β-D-erythro-pentofuranosyl)uracil; HO-dUrd
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxy-2'-Deoxyuridine is manufactured and tested under a strict quality management system. We provide material suitable for research and development use, with typical purity levels exceeding 95% (HPLC). Identity is confirmed by spectroscopic methods (NMR, IR, MS). Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.