Description

(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-Dimethyl-12-Oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-Tetradecahydrocyclopenta[A]Phenanthren-17-Yl]Pentanoic Acid is a high-purity steroidal intermediate of significant importance in advanced pharmaceutical synthesis. Its complex, defined stereochemistry makes it a critical building block for the development of novel therapeutic agents, particularly in the field of endocrinology. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of steroid-based drugs and reference standards.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) with steroidal backbones.
• Research & Development: Used in medicinal chemistry for the design, discovery, and structure-activity relationship (SAR) studies of new steroid hormone analogs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating steroid hormone metabolism, receptor binding, and enzymatic pathways.
• Process Chemistry: Utilized in the development and scale-up of synthetic routes for complex steroid molecules under GMP conditions.

Basic Information

Product Name	(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-Dimethyl-12-Oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-Tetradecahydrocyclopenta[A]Phenanthren-17-Yl]Pentanoic Acid
CAS No.	5130-29-0
Molecular Formula	C24H36O4
Molecular Weight	388.54 g/mol
Synonyms	17β-Carboxyethyl-3-hydroxyandrost-5-en-17-one; 3β-Hydroxy-5-androsten-17-one-17β-carboxylic acid; 17β-(3-Carboxypropyl)-3β-hydroxyandrost-5-en-17-one; 3β-Hydroxyandrost-5-ene-17β-carboxylic acid, 17β-propanoic acid derivative; Dehydroepiandrosterone-17β-carboxylic acid derivative; Steroid intermediate 5130-29-0; (4R)-4-[(8R,9S,10R,13S,14S,17R)-3-Hydroxy-10,13-dimethyl-12-oxo-1,2,6,7,8,9,11,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid (alternative IUPAC).
EINECS	Contact for details

Quality Control

Our (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-Dimethyl-12-Oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-Tetradecahydrocyclopenta[A]Phenanthren-17-Yl]Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de (by chiral HPLC)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.