Description

3-Deaza-4-Deoxyuridine is a synthetic nucleoside analogue, a modified derivative of deoxyuridine where a nitrogen atom in the pyrimidine ring is replaced by carbon. This structural modification is of significant interest in biochemical research, particularly for studying enzyme mechanisms and metabolic pathways involving nucleic acids. It serves as a valuable research tool for scientists in pharmaceutical development, oncology research, and molecular biology, where it is used to investigate nucleoside metabolism and as a potential precursor for antiviral or anticancer agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the specificity and mechanism of nucleoside-metabolizing enzymes like kinases and phosphorylases.
• Antiviral/Anticancer Research: Serves as a key intermediate or precursor in the synthesis and evaluation of novel nucleoside analogues with potential therapeutic activity.
• Metabolic Pathway Analysis: Employed as a tracer or probe to study the salvage pathways of pyrimidine nucleosides within cells.
• Enzyme Inhibition Studies: Acts as a tool compound to study the effects of nucleoside analogue incorporation on DNA/RNA polymerases and related enzymes.
• Academic & Pharmaceutical R&D: A critical reagent for universities, research institutes, and biotech companies engaged in drug discovery and fundamental life science research.

Basic Information

Product Name	3-Deaza-4-Deoxyuridine
CAS No.	5116-37-0
Molecular Formula	C9H13N3O4
Molecular Weight	227.22 g/mol
Synonyms	3-Deaza-2'-deoxyuridine; 4-Deoxy-3-deazauridine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-1,2-dihydropyrimidin-2-one; 3-Deazadeoxyuridine; 3-Deaza-dUrd; 3-Deaza-2'-deoxy-Uridine; 1-(2-Deoxy-β-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one
EINECS	Contact for details

Quality Control

We supply 3-Deaza-4-Deoxyuridine in high-purity grades suitable for research applications. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Standard analytical techniques including HPLC, NMR, and mass spectrometry are employed. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.