Description

5-Hydroxymethyl-2'-Deoxyuridine is a modified nucleoside derivative of deoxyuridine, featuring a hydroxymethyl group at the 5-position of the uracil base. This specific molecular modification makes it a valuable intermediate and building block in the synthesis of more complex nucleoside analogs and for biochemical research applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, nucleic acid chemistry, and the study of DNA metabolism and repair mechanisms.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or standard in enzymatic studies related to thymidylate synthase and other nucleotide metabolic pathways.
• DNA Modification Studies: Employed to investigate the incorporation and effects of modified bases in DNA, relevant to mutagenesis and repair processes.
• Antiviral Agent Development: Acts as a core structure for modifying to create potential therapeutic agents targeting viral polymerases.
• Labeled Compound Synthesis: A starting material for the preparation of isotopically labeled (e.g., 13C, 2H) nucleosides for tracer studies and metabolic profiling.
• Academic & Industrial R&D: Essential for basic research in molecular biology, medicinal chemistry, and for high-throughput screening libraries.

Basic Information

Product Name	5-Hydroxymethyl-2'-Deoxyuridine
CAS No.	5116-24-5
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	5-(Hydroxymethyl)-2'-deoxyuridine; HMdU; 5-Hydroxymethyldeoxyuridine; 5-HMdUrd; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(hydroxymethyl)pyrimidine-2,4-dione; 5-Hydroxymethyl-2'-deoxyuridine; 5-(Hydroxymethyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
EINECS	225-842-9

Quality Control

Our 5-Hydroxymethyl-2'-Deoxyuridine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR). A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.