Description

Guanabenz is a centrally acting α-2 adrenergic receptor agonist with significant pharmacological activity. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the research and development of antihypertensive and neurological therapeutics. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in neuropharmacology and cardiovascular drug development. Our Guanabenz CAS NO 5051-62-7 is supplied to meet the stringent quality demands of advanced pharmaceutical synthesis.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription medications for hypertension.
• Neurological Research: Investigational compound in studies targeting neurodegenerative diseases, including Huntington's and Alzheimer's, due to its effects on cellular stress pathways.
• Preclinical & Clinical Development: Serves as a key reference standard and bulk material for drug development programs from discovery through clinical trials.
• Chemical Synthesis Intermediate: Used in the synthesis of novel analogs and derivatives for structure-activity relationship (SAR) studies.
• Reference Standard: High-purity material for analytical method development, validation, and quality control testing in regulatory submissions.

Basic Information

Product Name	Guanabenz
CAS No.	5051-62-7
Molecular Formula	C8H8Cl2N4
Molecular Weight	231.08 g/mol
Synonyms	Guanabenz Acetate (common salt form); (2,6-Dichlorobenzylidene)amino guanidine; 1-(2,6-Dichlorobenzylideneamino)-3-aminoguanidine; WY-8678; BR-750; NSC-68973; CI-581; Benzylideneamino guanidine derivative
EINECS	225-752-5

Quality Control

Our Guanabenz is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various pharmacopeial monographs and customer-specific specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.