Description

Butyl Chloroformate is a versatile and highly reactive alkyl chloroformate ester, widely used as a key reagent in organic synthesis. Its primary value lies in its ability to act as an efficient coupling agent and protecting group for amines and alcohols, facilitating the production of carbamates, carbonates, and ureas. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and polymer industries, where it is instrumental in intermediate synthesis and fine chemical production.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for introducing the butyloxycarbonyl (Boc) protecting group in peptide synthesis and for preparing carbamate prodrugs.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides, where it forms stable carbamate linkages.
• Polymer Chemistry: Serves as a monomer or modifying agent in the production of polycarbonates, polyurethanes, and other specialty polymers.
• Chemical Derivatization: Employed to derivative amines and alcohols for analytical purposes, such as in gas chromatography or HPLC.
• Fine Chemical Production: Key building block for synthesizing various esters, carbonates, and urethane-based compounds.
• Cross-coupling Reactions: Acts as an activating agent in coupling reactions to form amide or ester bonds under mild conditions.

Basic Information

Product Name	Butyl Chloroformate
CAS No.	592-34-7
Molecular Formula	C5H9ClO2
Molecular Weight	136.58 g/mol
Synonyms	n-Butyl Chloroformate; Butyl Chlorocarbonate; Chloroformic Acid Butyl Ester; Butoxycarbonyl Chloride; BOC-Cl (common abbreviation); Carbonochloridic Acid, Butyl Ester; Butyl Carbonochloridate; n-Butyl Chloromethanoate
EINECS	209-746-0

Quality Control

Our Butyl Chloroformate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including assay, identity confirmation, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under a dry inert atmosphere (e.g., nitrogen) to prevent decomposition. Keep away from heat, sparks, open flames, strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Density at 20°C	1.07 - 1.09 g/mL
Refractive Index (n20D)	1.410 - 1.415
Water Content (KF)	≤ 0.1%
Acidity (as HCl)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.