Description

Debrisoquin Sulfate is a high-purity pharmaceutical reference standard and active pharmaceutical ingredient (API) intermediate. It is a selective and potent inhibitor of the cytochrome P450 enzyme CYP2D6, making it a critical tool for drug metabolism and pharmacogenetic research. This compound is essential for laboratories and manufacturers in the pharmaceutical, biotechnology, and clinical diagnostics sectors, particularly for in vitro studies, assay development, and quality control of related drug substances.

Application

• Pharmacogenetic Research: Used as a probe substrate and inhibitor to study the activity, polymorphism, and inhibition of the human cytochrome P450 enzyme CYP2D6.
• Drug Metabolism Studies: Employed in in vitro assays (e.g., microsomal incubations) to investigate metabolic pathways, drug-drug interactions, and enzyme kinetics.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification, assay, and impurity profiling of debrisoquine-related drug substances in quality control laboratories.
• Biomarker Analysis: Utilized in the development and calibration of analytical methods (LC-MS/MS, HPLC) for quantifying debrisoquine and its metabolites in biological samples.
• Clinical Diagnostics: Applied in phenotyping tests to determine an individual's CYP2D6 metabolic status, which is crucial for personalized medicine strategies.
• Academic & Contract Research: A key reagent for basic pharmacological research and preclinical studies in academic institutions and CROs (Contract Research Organizations).

Basic Information

Product Name	Debrisoquin Sulfate
CAS No.	581-88-4
Molecular Formula	C13H16N2 · H2SO4
Molecular Weight	304.35 g/mol
Synonyms	Debrisoquine Sulfate; Declinax; Ro 5-3307/1; 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, sulfate (1:1); Isocaramidine Sulfate; Debrisochin; (1,2,3,4-Tetrahydroisoquinolin-2-yl)guanidine sulfate
EINECS	Contact for details

Quality Control

Our Debrisoquin Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with research and pharmaceutical industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.