Description

Aureothricin is a naturally derived antibiotic compound belonging to the thiopeptide class, originally isolated from Streptomyces thioluteus. It exhibits potent inhibitory activity against Gram-positive bacteria by interfering with protein synthesis through binding to the 50S ribosomal subunit. Aureothricin CAS NO 574-95-8 is valued in research and development settings for its unique mechanism of action and structural complexity, supporting antimicrobial resistance (AMR) studies and novel therapeutic discovery. Key users include pharmaceutical R&D laboratories, academic microbiology departments, and contract research organizations engaged in antibiotic screening and mode-of-action characterization.

Application

• Antibiotic mechanism-of-action studies targeting bacterial ribosome function
• In vitro screening of novel antimicrobial agents against multidrug-resistant Staphylococcus aureus (MRSA) and Enterococcus strains
• Reference standard in HPLC and LC-MS/MS analytical method development and validation
• Tool compound for studying thiopeptide biosynthesis and post-translational modification pathways
• Lead structure for semi-synthetic derivatization programs aiming to improve pharmacokinetic properties
• Quality control reference material for fermentation-derived thiopeptide antibiotics
• Teaching applications in advanced medicinal chemistry and microbial pharmacology courses

Basic Information

Product Name	Aureothricin
CAS No.	574-95-8
Molecular Formula	C53H61N13O12S3
Molecular Weight	1204.35 g/mol
Synonyms	Aureothricin; Aureothricin A; Thiolutin; Thiolutin A; Streptothricin A; Streptothricin-A; NSC 13119; Antibiotic S-1; Thiolutin; Thiolutin A; 574-95-8; Streptothricin; Thiolutin (mixture)
EINECS	209-375-3

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Aureothricin are tested for identity (IR, HPLC retention time, MS), assay (HPLC), related substances (HPLC), residual solvents (GC), heavy metals (USP <231>), and microbiological purity (USP <61>). Testing follows ACS Reagent Grade and EP 11.0 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Heavy Metals	≤ 10 ppm
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.