Description

2-Bromopropionyl Bromide is a versatile and highly reactive acyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 2-bromopropionyl moiety, a key precursor for pharmaceuticals, agrochemicals, and functional materials. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable, high-purity reagent for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators, where the bromopropionyl group is incorporated into the final active compound.
• Polymer Chemistry: Acts as an initiator or functionalizing agent in controlled radical polymerization (e.g., Atom Transfer Radical Polymerization - ATRP) to create polymers with specific end-group functionality.
• Peptide & Protein Modification: Employed for the selective acylation of amino groups in peptides, proteins, and other biomolecules for research and bioconjugation applications.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science: Used in the surface functionalization of nanoparticles and other nanomaterials to alter their chemical properties and compatibility.

Basic Information

Item	Details
Product Name	2-Bromopropionyl Bromide
CAS No.	563-76-8
Molecular Formula	C3H4Br2O
Molecular Weight	215.87 g/mol
Synonyms	2-Bromopropanoyl Bromide; α-Bromopropionyl Bromide; Propionyl Bromide, 2-bromo-; 2-Bromopropionic Acid Bromide; Bromopropionyl Bromide; NSC 60548; 1-Bromo-1-oxopropan-2-yl Bromide; (2-Bromopropanoyl) Bromide
EINECS	209-250-5

Quality Control

Our 2-Bromopropionyl Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic (moisture-sensitive) and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Color (APHA)	≤ 50
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.