Description

(3A,5B,7A,12A)-3,7,12-Trihydroxy-Cholestan-26-Oic Acid is a key steroidal bile acid derivative, serving as a critical intermediate in the synthesis of complex pharmaceutical compounds and biochemical research. Its defined stereochemistry and functional groups make it an essential building block for developing therapeutic agents targeting metabolic and liver-related pathways. This high-purity intermediate is primarily required by manufacturers in the pharmaceutical, biotechnology, and advanced fine chemical sectors for research, process development, and commercial production.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of therapeutic bile acids and steroidal drugs.
• Biochemical Research: Used as a reference standard and substrate in metabolic pathway studies and enzyme assays.
• Fine Chemical Synthesis: Serves as a chiral starting material for the production of complex, high-value specialty chemicals.
• Metabolic Disorder Research: Investigated in studies related to cholesterol metabolism, liver function, and related disorders.
• API Development: Employed in the research and development of new Active Pharmaceutical Ingredients (APIs) with steroidal backbones.
• Diagnostic Reagents: Potential use in the formulation of calibration standards for clinical diagnostic kits.

Basic Information

Product Name	(3A,5B,7A,12A)-3,7,12-Trihydroxy-Cholestan-26-Oic Acid
CAS No.	547-98-8
Molecular Formula	C27H46O5
Molecular Weight	450.66 g/mol
Synonyms	3α,7α,12α-Trihydroxy-5β-cholestan-26-oic Acid; 5β-Cholestane-3α,7α,12α-triol-26-oic Acid; Trihydroxycholestanoic Acid; THCA; (25R)-3α,7α,12α-Trihydroxy-5β-cholestan-26-oic Acid; 3α,7α,12α-Trihydroxy-27-nor-5β-cholestan-24-oic Acid (related); Varanic Acid (common name)
EINECS	Contact for details

Quality Control

Our (3A,5B,7A,12A)-3,7,12-Trihydroxy-Cholestan-26-Oic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.