Description

14β-Hydroxybufa-3,5,20,22-Tetrenolide is a specialized steroidal compound with a complex bufadienolide structure. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of cardiac glycosides and other bioactive steroid derivatives. The compound, identified by CAS 545-51-7, is supplied under stringent quality control to ensure consistency for sensitive applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex bufadienolide derivatives and other steroidal drugs.
• Biochemical Research: Used as a reference standard or active compound in studies investigating Na+/K+-ATPase inhibition and cardiac activity.
• Preclinical Development: Employed in the discovery and development stages of new therapeutic agents targeting heart failure and related conditions.
• Academic Research: Utilized in university and institutional labs for studying the structure-activity relationships (SAR) of cardiac glycosides.
• Fine Chemical Synthesis: Acts as a precursor for the preparation of more complex, functionally modified steroid molecules.

Basic Information

Product Name	14β-Hydroxybufa-3,5,20,22-Tetrenolide
CAS No.	545-51-7
Molecular Formula	C₂₄H₃₂O₅
Molecular Weight	400.51 g/mol
Synonyms	14β-Hydroxybufa-3,5,20,22-tetraenolide; 14β-Hydroxybufalin; 3β,14β-Dihydroxybufa-20,22-dienolide; Bufalin-14-ol; NSC 83265; 14-Hydroxybufalin; Bufadienolide, 3,14-dihydroxy-; 5β,14β-Bufa-20,22-dienolide-3,14-diol
EINECS	Contact for details

Quality Control

Our 14β-Hydroxybufa-3,5,20,22-Tetrenolide is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with research-grade standards. We are committed to supplying material of consistent high quality to support reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.