Description

14-Hydroxy-3-Oxobufa-4,20,22-Trienolide is a specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel cardioactive steroids and other therapeutic molecules.
• Biochemical Research: Used as a reference standard or active compound in pharmacological studies targeting ion channels and cellular signaling pathways.
• Preclinical Development: Serves as a starting material for the development of new chemical entities (NCEs) in drug discovery pipelines.
• Natural Product Synthesis: Employed in the semi-synthesis or total synthesis of complex bufadienolides and related natural products.
• API Development: Investigated for use in the development of Active Pharmaceutical Ingredients (APIs) with specific biological targets.

Basic Information

Item	Details
Product Name	14-Hydroxy-3-Oxobufa-4,20,22-Trienolide
CAS No.	545-28-8
Molecular Formula	C₂₄H₃₂O₅
Molecular Weight	400.51 g/mol
Synonyms	14-Hydroxy-3-oxobufa-4,20,22-trienolide; 3-Oxo-14-hydroxybufa-4,20,22-trienolide; Bufadienolide derivative; 14-Hydroxybufalinone; Telocinobufagin 3-ketone; 3-Ketotelocinobufagin; 3-Oxotelocinobufagin; 14-Hydroxy-3-oxo-δ⁴,²⁰,²²-bufatrienolide
EINECS	Contact for details

Quality Control

Our 14-Hydroxy-3-Oxobufa-4,20,22-Trienolide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.