Description

Gitoxigenin is a cardenolide aglycone, a key intermediate and reference standard derived from cardiac glycosides. This high-purity compound is essential for pharmaceutical research and development, particularly in the study of cardiac pharmacology and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in cardiovascular drug discovery and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and purity testing of related cardiac glycosides and their derivatives in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical building block in the synthetic pathways for novel cardiotonic and anticancer agents.
• Biochemical Research: Employed in pharmacological studies to investigate the mechanism of action of Na+/K+-ATPase inhibition and its effects on cardiac muscle contractility.
• Analytical Chemistry: Utilized for method development and validation in chromatographic techniques (HPLC, LC-MS) for the quantification of cardenolides in complex matrices.
• Academic Research: Applied in university and institutional labs for structure-activity relationship (SAR) studies and the development of new therapeutic compounds.

Basic Information

Product Name	Gitoxigenin
CAS No.	545-26-6
Molecular Formula	C₂₃H₃₄O₅
Molecular Weight	390.51 g/mol
Synonyms	16β-Hydroxygitoxigenin; 3β,16β-Dihydroxy-5β,14β-card-20(22)-enolide; Anhydrogitalin; Gitoxigenin; (3β,5β,16β)-3,16-Dihydroxycard-20(22)-enolide; 16β-Hydroxygitoxigenin; NSC 7525
EINECS	208-884-1

Quality Control

Our Gitoxigenin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.