Description

Isobutyl Chloroformate is a versatile and highly reactive alkyl chloroformate ester widely used as a key reagent in organic synthesis. Its primary value lies in its ability to function as an efficient coupling agent and protecting group, facilitating the formation of carbonates, carbamates, and esters under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for peptide synthesis and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of carbamate prodrugs and for introducing the isobutyloxycarbonyl (iBoc) protecting group in peptide and nucleotide chemistry.
• Agrochemical Production: Used in the manufacture of herbicides, fungicides, and insecticides where it acts as a building block for active ingredients.
• Polymer Chemistry: Serves as a modifier and cross-linking agent in the production of specialty polymers and polycarbonates.
• Chemical Synthesis: Employed as a coupling agent for the preparation of mixed carbonic anhydrides and for the esterification of sensitive acids.
• Bioconjugation: Utilized in biochemical research for labeling and modifying biomolecules such as proteins and peptides.
• Dye and Pigment Industry: Acts as an intermediate in the synthesis of certain organic dyes and colorants.

Basic Information

Product Name	Isobutyl Chloroformate
CAS No.	543-27-1
Molecular Formula	C5H9ClO2
Molecular Weight	136.58 g/mol
Synonyms	Isobutyl chlorocarbonate; Chloroformic acid isobutyl ester; Isobutoxycarbonyl chloride; i-Butyl chloroformate; Carbonochloridic acid, 2-methylpropyl ester; 2-Methylpropyl chloroformate; Isobutyl carbonochloridate
EINECS	208-843-8

Quality Control

Our Isobutyl Chloroformate is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to current Good Manufacturing Practices (cGMP) where applicable. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We support compliance with global regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified for the specific grade. This product is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Density (at 20°C)	1.05 - 1.07 g/mL
Refractive Index (n20D)	1.405 - 1.415
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.