Description

Dimethoxanate Hydrochloride is a pharmaceutical-grade active pharmaceutical ingredient (API) primarily used as a non-opioid antitussive agent. This compound matters for its targeted action in suppressing the cough reflex, offering a critical therapeutic option in respiratory formulations. It is needed by pharmaceutical manufacturers and R&D laboratories developing cough syrups, lozenges, and other respiratory medications for the global healthcare market.

Application

• Primary Pharmaceutical Ingredient: Core active component in prescription and over-the-counter (OTC) antitussive (cough suppressant) formulations.
• Cough Syrup Production: Used in the manufacture of liquid oral suspensions and syrups for effective cough management.
• Lozenge and Tablet Formulation: Incorporated into solid oral dosage forms for prolonged relief and patient convenience.
• Respiratory Research & Development: Serves as a key reference standard and intermediate in pharmacological studies for new respiratory therapies.
• Veterinary Pharmaceutical Applications: Employed in the development of cough suppressants for animal health.
• Analytical Reference Standard: Used in quality control (QC) laboratories for HPLC, GC, or spectroscopic method development and validation.

Basic Information

Product Name	Dimethoxanate Hydrochloride
CAS No.	518-63-8
Molecular Formula	C19H25NO3·HCl
Molecular Weight	351.87 g/mol (as hydrochloride salt)
Synonyms	Dimethoxanate HCl; 2-(2-Dimethylaminoethoxy)ethyl 10H-Phenothiazine-10-carboxylate Hydrochloride; Cotrane; Peracon; Tussidin; Tussizid; Antitussive 246
EINECS	Contact for details

Quality Control

Our Dimethoxanate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.