Description

Podophyllotoxin is a potent aryltetralin lignan, a key natural product and pharmaceutical intermediate derived from *Podophyllum* species. Its unique chemical structure serves as the critical scaffold for the semi-synthesis of important anticancer and antiviral agents. This high-purity compound is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and fine chemical sectors requiring a reliable, high-quality building block for advanced therapeutics.

Application

• Pharmaceutical Intermediate: Primary precursor for the semi-synthesis of chemotherapeutic agents etoposide, teniposide, and etopophos.
• Antiviral Agent Production: Used in research and development of topical treatments for conditions caused by human papillomavirus (HPV).
• Biochemical Research: Valuable reference standard and tool compound for studying tubulin polymerization inhibition and cell cycle arrest mechanisms.
• Fine Chemical Synthesis: Serves as a chiral starting material for the synthesis of complex natural product analogs and novel bioactive molecules.
• Cosmetic & Dermatological Research: Investigated for potential applications in targeted topical formulations due to its specific biological activity.

Basic Information

Product Name	Podophyllotoxin
CAS No.	518-28-5
Molecular Formula	C22H22O8
Molecular Weight	414.41 g/mol
Synonyms	Podofilox; Condylox; 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; (-)-Podophyllotoxin; NSC 24818; Picropodophyllin isomer; Podophyllinic acid lactone
EINECS	208-261-5

Quality Control

Our Podophyllotoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and heavy metals. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.