Description

α-Cortolone is a significant steroid intermediate, also known as 5β-Pregnane-3α,11β,17α,20α,21-pentol. This compound is a key building block in the synthesis of various corticosteroid pharmaceuticals, valued for its specific stereochemistry and functional groups. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of anti-inflammatory and hormonal therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of corticosteroid drugs such as hydrocortisone and its derivatives.
• Biochemical Research: Used as a reference standard or starting material in metabolic pathway studies and steroid hormone research.
• Process Development: Serves as a key material for optimizing synthetic routes and scaling up production of complex steroid molecules.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the controlled synthesis of final steroid APIs requiring high purity and specific isomeric forms.

Basic Information

Item	Detail
Product Name	α-Cortolone
CAS No.	516-42-7
Molecular Formula	C21H34O5
Molecular Weight	366.49 g/mol
Synonyms	5β-Pregnane-3α,11β,17α,20α,21-pentol; 3α,11β,17α,20α,21-Pentahydroxy-5β-pregnane; 20α-Hydroxycortolone; 11β,17α,20α,21-Tetrahydroxypregnane-3-one; Cortolone; α-Cortolone; 5β-Pregnane-3α,11β,17α,20α,21-pentaol
EINECS	Contact for details

Quality Control

Our α-Cortolone is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.