Description

1-[(3S,8S,9S,10R,13R,14S,17S)-3-Methoxy-10,13-Dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-Dodecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl]Ethanone is a high-purity steroidal ketone derivative, serving as a critical advanced intermediate in complex organic synthesis. Its defined stereochemistry and functional groups make it invaluable for research and development in the pharmaceutical sector, particularly for the synthesis of novel therapeutic agents and reference standards. This compound is essential for R&D chemists and process development scientists working in steroid chemistry, medicinal chemistry, and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel steroid-based drugs and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new therapeutic candidates targeting hormone receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex steroidal molecules.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study enzyme interactions and metabolic pathways involving steroidal frameworks.
• Fine Chemical Synthesis: A versatile intermediate for creating specialized steroidal derivatives with modified biological activity.

Basic Information

Product Name	1-[(3S,8S,9S,10R,13R,14S,17S)-3-Methoxy-10,13-Dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-Dodecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl]Ethanone
CAS No.	511-26-2
Molecular Formula	C22H34O2
Molecular Weight	330.51 g/mol
Synonyms	3-Methoxyestra-1,3,5(10)-trien-17-one; 3-Methoxy-1,3,5(10)-estratrien-17-one; 3-Methoxyestra-1,3,5(10)-trien-17-one; 17-Oxo-3-methoxyestra-1,3,5(10)-triene; 3-Methoxyestra-1,3,5(10)-triene-17-one; 3-Methoxy-19-nor-17α-pregna-1,3,5(10)-trien-20-one (related structure); 3-Methoxyestra-1,3,5-triene-17-one
EINECS	208-133-5

Quality Control

Our 1-[(3S,8S,9S,10R,13R,14S,17S)-3-Methoxy-10,13-Dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-Dodecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl]Ethanone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.