Description

5-(β-D-Glucopyranosyloxy)-14-Hydroxy-19-Oxo-5β-Bufa-3,20,22-Trienolide is a specialized cardiac glycoside derivative, a compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its unique structural framework, which serves as a critical intermediate or reference standard for the synthesis and study of novel bioactive molecules. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, well-characterized materials for drug discovery, process development, and analytical method validation. The compound, identified by CAS No. 510-58-7, is supplied under stringent quality controls to ensure batch-to-batch consistency for sensitive applications.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Drug Discovery & Medicinal Chemistry: Acts as a key intermediate or lead compound for the synthesis and structural modification of novel therapeutic agents targeting cardiac function.
• Biochemical Research: Used in pharmacological studies to investigate mechanisms of action related to sodium-potassium ATPase inhibition and cardiac activity.
• Academic Research: Employed in university and institutional labs for studying the structure-activity relationships (SAR) of bufadienolide and cardenolide classes of compounds.
• Analytical Testing: Utilized as a high-purity calibrant in advanced chromatographic (HPLC, LC-MS) and spectroscopic analyses.

Basic Information

Item	Detail
Product Name	5-(β-D-Glucopyranosyloxy)-14-Hydroxy-19-Oxo-5β-Bufa-3,20,22-Trienolide
CAS No.	510-58-7
Molecular Formula	C30H42O10
Molecular Weight	562.65 g/mol
Synonyms	Gamabufotalin 3-O-glucoside; Gamabufotalin glucoside; 3β-[(β-D-Glucopyranosyl)oxy]-14,19-dihydroxy-5β-bufa-20,22-dienolide; 19-Oxogamabufotalin 3-O-β-D-glucoside; 5β-Bufa-3,20,22-trienolide, 14,19-dihydroxy-3-[(β-D-glucopyranosyl)oxy]-, (3β,5β)-; Helveticoside; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 5-(β-D-Glucopyranosyloxy)-14-Hydroxy-19-Oxo-5β-Bufa-3,20,22-Trienolide is manufactured and analyzed under a strict quality management system. Our products undergo rigorous identity, purity, and impurity profile testing using advanced techniques like HPLC, LC-MS, and NMR to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing all test results, including assay purity, related substances, residual solvents, and specific optical rotation, is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept in a dry environment and opened under appropriate conditions to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Optical Rotation	Provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.